C07 - Changing behaviour, changing brain, changing obesity

Rewarding stimuli, such as tasty food, induce approach behaviour, whereas aversive stimuli lead to avoidance behaviour. Turning the tables, an instructed approach behaviour towards an option increases its reward value, whereas an instructed avoidance behaviour away from an option decreases its reward value. Here, we propose a focussed short-term behavioural training that applies this principle to induce long-term change in food-intake behaviour and related neural activity in lean and obese subjects. A series of experiments will be conducted, partly with the help of functional magnetic resonance imaging. These studies will contribute significantly to the development of potential intervention methods for obesity.