B03 - Investigating hormonal modulation of dopaminergic mechanisms underlying impulsivity

Midbrain dopaminergic neurons and basal cortical ganglia circuits have long been implicated in mediating reward behaviour and play an important role in impulsive behaviour. Understanding disease mechanisms in impulse control disorders requires that we establish formal models which link specific components of dopaminergic reward circuits to individual differences in the expression of impulsive behaviour and differentiate between distinct types of reward (e.g. food vs. money). In this project we apply computational modelling techniques to human neuroimaging and behavioural data with the goal of obtaining quantitative in vivo markers of dopaminergic transmission and its modulation by hormones, which promise to predict individual expressions of impulsivity.