A06 - Inflammatory signalling in the hedonic regulation of feeding

Both leptin and the inflammatory mediator IL-6 can inhibit hedonic aspects of appetite control and both can signal via NF-κB at target sites. We will activate/inhibit NF-κB signalling in various cell types in the CNS using genetic and viral tools to investigate the effects of leptin and IL-6 on food preference of mice as a paradigm of hedonic feeding behaviour. Using, both loss and gain of function approaches we will characterize hedonic aspects of feeding in mouse mutants carrying disruptions or activations of IL-6 signalling in all neurons or specifically in the dopaminergic system. These experiments shall unravel the role of inflammatory signalling in the central regulation of hedonic feeding behaviour and reward.

Viral expression of the GFP reporter in the arcuate nucleus of mice
Viral expression of the GFP reporter in the arcuate nucleus of mice