A04 - Role of orexin signalling in energy homeostasis and reward processing

The hypothalamus integrates hormonal and neuronal signals to regulate appetite and energy metabolism and, thus, plays a crucial role in the homeostatic control of body weight. Additional neuronal circuits such as the dopaminergic and serotonergic systems of the brain can influence and eventually override this system. Recent studies suggest that orexinergic neurons in the lateral hypothalamus interact with both systems to integrate processes that regulate body weight, reward and sleep/wake states. The aim of this project is to define the role of orexin signalling in the cross-talk between homeostatic and hedonic circuits in control of energy homeostasis.