A02 - Dissecting the relationship between Insulin signalling and reward regulation
Homeostatic feedback mediated by hormones such as insulin and leptin and environmental cues evaluated by the reward system in concert regulate appetite and food intake. The aim of this project is to analyse the functional interaction between the reward system and insulin-receptive neurons using neuroanatomical, molecular, genetic and behavioural approaches. We will opto-genetically dysregulate both systems in various combinations and analyse the consequences on food intake and body weight regulation using Drosophila as a model system. The analysis of differential contributions of both systems to appetite regulation will help to uncover the mechanistic basis of misregulated eating behaviours.