A06 - Inflammatory signalling in the hedonic regulation of feeding

Both leptin and the inflammatory mediator IL-6 can inhibit hedonic aspects of appetite control and both can signal via NF-κB at target sites. We will activate/inhibit NF-κB signalling in various cell types in the CNS using genetic and viral tools to investigate the effects of leptin and IL-6 on food preference of mice as a paradigm of hedonic feeding behaviour. Using, both loss and gain of function approaches we will characterize hedonic aspects of feeding in mouse mutants carrying disruptions or activations of IL-6 signalling in all neurons or specifically in the dopaminergic system. These experiments shall unravel the role of inflammatory signalling in the central regulation of hedonic feeding behaviour and reward.