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The principal aim of the Transregional Collaborative Research Centre (T-CRC) is to examine and define the interaction between homeostatic and hedonic pathways and processes in the regulation of eating behaviour on a molecular, behavioural, and neural / neuroimaging level with a particular focus on differences between normal-weight and obese persons. We propose that a functional and balanced interaction between both systems is key to the physiological regulation of food intake, body weight and body composition. Perturbations of this interaction will lead to the development and maintenance of body weight gain. Therefore, the long-term goal of this T-CRC is to identify and design specific interventions that may readjust the balance between homeostatic and hedonic processing of food-related signals, thus counteracting the development of adverse habits in food intake and obesity.